Protein Purification Jobs in Bengaluru

Job Title: Senior R&D Scientist Downstream, Fast Trak Process Design & Validation Services Location: Bengaluru, India About the Role: We are seeking a Senior R&D Scientist Downstream to lead the technical development and execution of new or improved services aligned with our R&D strategic initiatives. This role focuses on downstream process development services and spans the full innovation cycle from defining specifications and designing solutions to validation and market launch support. You will work in close collaboration with R&D project managers and cross-functional teams to bring new bioprocess services to life. Key Responsibilities: Serve as the technical lead on innovation projects, working closely with R&D project managers and relevant departments to ensure successful project execution. Define and document technical specifications for new service and product developments based on customer and market requirements. Plan, execute, and report on technical studies, including risk assessments and experimental design, throughout various project stages. Lead and conduct verification and validation studies to ensure new services/products meet both technical and marketing requirements. Oversee lab setup and documentation in preparation for service commercialization. Ensure compliance with Environment, Health & Safety (EHS) standards and regulatory guidelines within laboratory operations. Qualifications: Bachelor s, Master s, or Ph.D. in Molecular Biology, Biochemistry, Bioengineering, or a related scientific discipline. Minimum of 5 years of hands-on experience leading and delivering technical projects in a scientific or bioprocessing environment. Proven ability to work independently, troubleshoot complex problems, and think creatively to develop practical solutions. Experience managing multiple projects in parallel, with strong organizational and time-management skills. Excellent communication, reporting, and presentation skills, with the ability to tailor information to both technical and non-technical stakeholders. Preferred Experience: Familiarity with aseptic laboratory techniques. Working knowledge of Good Laboratory Practice (GLP). Experience in upstream or downstream biotechnology unit operations. Qualification : Bachelors, Masters, or Ph.D. in Molecular Biology, Biochemistry, Bioengineering, or a related scientific discipline.

Key Responsibilities: Primary Cells & Cell Lines: Work with primary cells and cell lines in the context of immunology and immuno-oncology, with experience in developing and validating cell and gene therapy products. Cell-Based Assay Development: Lead the development and execution of cell-based assays, including immunological and immuno-oncological assays, for assessing the efficacy and safety of therapeutic products. Molecular Biology Techniques: Apply molecular biology techniques such as PCR, qPCR, cloning, and real-time PCR to analyze cellular responses and validate product candidates. Flow Cytometry & Sorting: Utilize flow cytometry and sorting techniques for detailed cell characterization, analysis of immune responses, and product quality control. Cross-Functional Collaboration: Collaborate closely with internal teams across manufacturing, quality assurance, clinical development, and supply chain management to advance the cell therapy pipeline. External Collaboration: Engage and coordinate with external collaborators, including contract research organizations (CROs) and vendors, to ensure smooth development and execution of the cell therapy product lifecycle. Project Management: Exhibit strict adherence to project timelines, ensuring that all work is completed on time while maintaining the highest standards of accuracy, integrity, safety, and quality. SOP & Documentation: Prepare and review Standard Operating Procedures (SOPs), protocols, regulatory documents, and reports in alignment with program requirements and compliance guidelines. Sterile Practices & Compliance: Adhere to systems and processes related to sterile practices, safety protocols, work ethics, and environmental health and safety standards. Key Skills: Cell-Based Assays: Expertise in the development and execution of cell-based assays, especially in immunology and immuno-oncology contexts. Ability to assess immune responses and therapeutic efficacy. Immuno-Oncology Knowledge: Deep understanding of immuno-oncology, including cellular and molecular mechanisms of cancer immunity, and how to translate this knowledge into therapeutic strategies. Molecular Biology Techniques: Proficiency in molecular techniques like PCR, qPCR, cloning, and real-time PCR for gene expression analysis, assay development, and validation. Flow Cytometry & Sorting: Expertise in flow cytometry, sorting, and analysis of cellular subsets, with an understanding of how these techniques can be applied to immuno-oncology. Stable Cell Line Generation: Experience in generating and maintaining stable cell lines for therapeutic and assay development purposes. Cross-Functional Team Collaboration: Proven ability to effectively work and communicate within a highly matrixed team environment, working across various functional areas to achieve product development goals. Vendor Management: Strong experience in managing external vendors, including CROs and service providers, ensuring timely and quality execution of outsourced activities. Competencies: Immunological and Immuno-Oncological Expertise: In-depth knowledge of immunology and immuno-oncology, with practical application to cell therapy development. Molecular Biology: Expertise in PCR, qPCR, cloning, and other molecular techniques used for gene analysis and validation of cell therapy products. Effective Communication: Strong verbal and written communication skills, with the ability to present complex data clearly and interact effectively with both internal and external stakeholders. Collaboration & Teamwork: Excellent interpersonal skills, able to collaborate effectively within teams and across functions to drive the progress of the cell therapy pipeline. Project Management: Ability to adhere to timelines and manage multiple projects effectively, ensuring that deadlines are met while maintaining quality and compliance. Vendor & Stakeholder Management: Competency in managing relationships with external partners, ensuring that project goals and deliverables are met to the required standard. Qualification : M.Sc. / MTech in Biotechnology with 3-7 years of experience in GMP Production

Scope: This role is responsible for executing chemical reactions to synthesize the required quantities of molecules/compounds as per client specifications, employing efficient synthetic routes and techniques. Key Responsibilities: Reaction Setup & Execution: Understand and follow project requirements, including the synthetic route as specified by the client. Plan and execute reactions using the appropriate reagents and equipment (glassware, stirrers, vacuum pumps, etc.) while maintaining specified conditions (temperature, pressure, etc.). Ensure the parallel execution of multiple reactions, meeting productivity benchmarks for reactions, steps, compounds, and timelines. Monitor reaction progress using analytical techniques, making adjustments as necessary to ensure high quality and yield. Execute appropriate workup and purification techniques to achieve intermediates and final compounds of desired quality. Safety & Risk Mitigation: Discuss and understand the Material Safety Data Sheets (MSDS) with team members to ensure awareness of safety protocols. Identify potential safety risks and mitigate them with the help of a supervisor, ensuring safe lab practices. Follow all safety and quality control systems and maintain proper equipment use as per SOPs and laboratory housekeeping norms. Data Integrity & Reporting: Maintain strict documentation of reactions, observations, and research findings in lab notebooks to ensure data integrity. Ensure compliance with IP confidentiality policies and document results as per client specifications. Prepare final reports to summarize synthesis processes, results, and quality assessments. Team Development & Morale: Foster a learning environment by improving team members knowledge in organic chemistry (synthesis) and analytical techniques through one-on-one discussions, training programs, and educational sessions. Support team skill development and ensure a positive, productive atmosphere in the lab. Functional/Technical Skills: Chemistry Knowledge: Expertise in organic chemistry, particularly in the execution of synthetic reactions and compound synthesis. Safety Protocols: Proficiency in applying safety protocols and ensuring laboratory safety. Data Integrity & IP Confidentiality: Strong understanding of the importance of data integrity and adherence to IP confidentiality guidelines. Resource Management: Ability to perform cost-benefit analysis, optimizing the use of reagents, resources, and equipment for efficient lab operation. Required Qualifications & Experience: Educational Qualification: M.Sc. in Organic or Medicinal Chemistry with 1-5 years of relevant experience. Preferred Qualifications: Candidates with research publications in leading scientific journals are preferred. Qualification : M.Sc. in Organic or Medicinal Chemistry with 1-5 years of relevant experience.

Scope: This role is responsible for executing chemical reactions to synthesize required quantities of molecules/compounds according to client specifications, utilizing efficient synthetic routes and techniques. Key Responsibilities: Reaction Setup & Execution: Understand and execute reactions for synthesizing target molecules/compounds according to project specifications. Plan and execute reactions using proper reagents and equipment (e.g., glassware, stirrers, vacuum pumps) while maintaining specified conditions (temperature, pressure). Ensure parallel execution of multiple reactions. Safety & Risk Mitigation: Discuss and understand the Material Safety Data Sheet (MSDS) with team members. Identify and mitigate potential safety risks with supervisor guidance. Follow safety and quality systems, maintaining laboratory housekeeping and proper equipment usage. Analysis & Reporting: Monitor the reaction progress using analytical techniques. Identify and apply appropriate workup and purification techniques to produce high-quality intermediate/final compounds. Analyze, evaluate, and interpret analytical data from synthesis, providing accurate reports. Document reactions, research findings, and observations in lab notebooks to ensure data integrity. Productivity & Compliance: Meet productivity benchmarks regarding the number of reactions, steps, compounds, quality, and timelines. Maintain strict IP confidentiality and adhere to all policies regarding data integrity. Prepare final reports as required by clients and internal stakeholders. Team Development: Foster a learning environment by improving team knowledge in organic chemistry and analytical techniques. Conduct one-on-one discussions, classroom training, and project-based training to enhance skills. Ensure the team s morale and productivity through continuous skill development. Functional/Technical Skills: Chemistry Expertise: Knowledge of organic chemistry, particularly synthesis and execution techniques. Safety Compliance: Strong understanding of safety protocols in laboratory environments. IP & Confidentiality: Awareness of IP protection, confidentiality, and maintaining data integrity. Resource Optimization: Ability to conduct cost-benefit analysis and ensure the optimum usage of resources. Required Qualifications: Educational Requirements: M.Sc. in Organic/Medicinal Chemistry with 1 5 years of relevant experience. Preferred Qualifications: Candidates with research publications in leading journals are preferred. Equal Employment Opportunity Statement: Aragen provides equal employment opportunities to all individuals regardless of age, color, national origin, citizenship status, mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity, genetic information, marital status, veteran status, or any characteristic protected by applicable legislation or local law. Reasonable accommodations will be provided for qualified individuals with disabilities. Qualification : M.Sc. in Organic/Medicinal Chemistry with 15 years of relevant experience.

Key Responsibilities: Cell Therapy Product Development: Lead the development of new cell therapy products, overseeing the validation process to ensure successful transition to the next stage of product development. Cell Culture Techniques: Apply extensive experience in different types of cell culture techniques, ensuring the optimal growth and maintenance of cells required for therapy products. Large-Scale Bioreactor Operations: Oversee the operation of large-scale bioreactors for biologicals, catering to both commercial and clinical requirements. Ensure that all aseptic operations are performed to the highest standards. Gene Transfer Methods: Utilize and manage both viral and non-viral methods of gene transfer, incorporating these techniques into cell therapy protocols. Equipment and Facility Maintenance: Maintain equipment and facilities in compliance with industry standards, ensuring the implementation of effective calibration, preventive maintenance, and validation programs. Documentation & Reporting: Prepare and review cGMP-compliant documentation, including SOPs, batch records, checklists, protocols, and reports. Ensure that all documentation is accurate and up to date for regulatory purposes. Team Leadership & Collaboration: Lead a team, providing critical technical and scientific recommendations, troubleshooting, and fostering innovation. Manage the day-to-day activities of team members while encouraging excellence in all aspects of work. Cross-Functional Collaboration: Work closely with cross-functional teams to advance the company s cell therapy pipeline, collaborating effectively in a matrixed team environment. Production Planning: Organize workflow by assigning responsibilities and preparing work schedules to ensure that production targets are met efficiently. Adherence to Project Timelines: Exhibit strict adherence to project timelines, ensuring that quality, safety, integrity, and accuracy are maintained throughout the development and production process. Sterile Practices & Compliance: Understand and enforce systems and processes related to sterile practices, safety protocols, work ethics, and environmental health standards. Key Skills: Cell Therapy Development: In-depth experience in the development of cell therapy products, with the ability to manage the entire development lifecycle from early-stage research through to product validation. Cell Culture Expertise: Expertise in cell culture techniques, both in small and large-scale systems, ensuring cell integrity and performance for clinical and commercial applications. Bioreactor & Aseptic Operations: Proficiency in large-scale bioreactor operations and aseptic techniques, ensuring contamination-free environments for cell and tissue production. Gene Transfer Methods: Hands-on experience in viral and non-viral gene transfer methods, including plasmid DNA transfections and viral vector-based techniques, critical for gene therapy applications. cGMP Documentation: Familiarity with preparing and reviewing cGMP documents, such as SOPs, protocols, and batch records, ensuring compliance with regulatory requirements. Team Management: Leadership skills to manage, guide, and motivate a team, ensuring high levels of collaboration, productivity, and excellence. Problem-Solving & Troubleshooting: Excellent troubleshooting skills, with the ability to innovate and provide technical solutions in the face of operational challenges. Cross-Functional Collaboration: Ability to collaborate across various teams and functions, working towards shared goals and the successful advancement of the cell therapy pipeline. Project & Time Management: Ability to manage multiple projects simultaneously, ensuring that work is completed on time while maintaining high quality and safety standards. Competencies: Leadership & Team Development: Strong leadership skills, with the ability to direct and motivate a team, fostering an environment of growth, innovation, and high performance. Communication Skills: Excellent verbal, written, and presentation skills, with experience in writing grants and research articles. Ability to effectively communicate with internal teams, external collaborators, and stakeholders. Attention to Detail: High attention to detail, ensuring accuracy and precision in all aspects of product development, documentation, and operational procedures. Problem-Solving & Innovation: Ability to troubleshoot and solve complex scientific problems, utilizing innovative approaches to overcome technical and operational challenges. Adaptability & Efficiency: Demonstrated ability to adapt to changing priorities and work in fast-paced, high-pressure environments while maintaining efficiency and meeting production targets. Quality & Safety Focus: Strong focus on maintaining high standards of safety, quality, and compliance throughout all phases of cell therapy development and production. Qualification : M.Sc. / MTech in Life Sciences with 12-18 years of experience in GMP Productioninvolving intense Cell Culture

Key Responsibilities: QMS Documentation & Activities: Expertise in preparing and managing QMS (Quality Management System) documentation related to facility and engineering activities, including writing SOPs for lab instruments, equipment, and utilities, as well as preparing qualification documents (DQ, IQ, OQ, PQ), deviation handling, change control, risk assessment, CAPA, and commissioning documents. Cross-functional Collaboration: Work closely with both internal teams and external stakeholders to ensure the smooth implementation and execution of engineering maintenance activities. This includes document preparation, process review, implementation, and follow-ups with various functional teams and vendors. Facility Modification & Commissioning: Manage facility modification projects, including overseeing commissioning and qualifications documentation to ensure that changes are aligned with regulatory and operational standards. Lab Equipment Operations & Maintenance: Oversee the operation and maintenance of lab equipment, including CO2 incubators, deep freezers, autoclaves, biosafety cabinets, LAF, stability chambers, cooling incubators, lab centrifuges, water baths, hot air ovens, incubator shakers, water purification systems, bioreactors, cold rooms, and liquid nitrogen systems. Analytical Instrument Operations & Maintenance: Manage the operation and maintenance of analytical instruments such as flow cytometers, spectrophotometers, multimode microplate readers, chemical image systems, gel image systems, osmometers, pH & conductivity meters, weighing balances, and western blot instruments. Utility Equipment Maintenance: Manage the operation and maintenance of HVAC systems (including air handling units, chillers, cooling towers, and BMS monitoring systems), utility equipment such as transformers, DG sets, air compressors, nitrogen generators, and LT panels. Preventive Maintenance Planning: Prepare and review schedules for periodic maintenance of lab instruments, utility equipment, and facility infrastructure. Ensure that all maintenance activities are conducted timely and in accordance with operational needs. Corrective and Preventive Actions: Coordinate and oversee corrective and preventive actions related to observations during internal and external audits, ensuring continuous compliance with quality standards. Vendor and OEM Coordination: Serve as the primary point of contact for external vendors and OEM service providers for periodic preventive maintenance (PM), calibration activities, and addressing breakdown issues. Project & Facility Modification Support: Coordinate and support the execution, verification, and successful completion of new projects or facility modification activities. Safety and Sustainability: Ensure compliance with safety practices and procedures, sustainability programs, and hygiene maintenance standards across the facility. Key Skills: QMS Documentation: In-depth experience in writing and managing SOPs and qualification documents (DQ, IQ, OQ, PQ) for lab instruments and utility systems. Proficient in handling deviations, change controls, risk assessments, CAPA, and commissioning documentation. Lab Equipment Expertise: Strong knowledge in the operation and maintenance of various lab equipment, including incubators, freezers, autoclaves, biosafety cabinets, stability chambers, centrifuges, and water purification systems. Analytical Instruments Management: Expertise in handling and maintaining analytical instruments like flow cytometers, spectrophotometers, microplate readers, and various other lab-based instruments used for experiments and analysis. Utility Systems & HVAC Management: Strong knowledge of utility equipment management, including HVAC systems, transformers, DG sets, air compressors, and nitrogen generators. Preventive & Corrective Maintenance: Ability to plan, schedule, and execute preventive and corrective maintenance tasks for lab instruments and utility systems, ensuring minimal downtime. Vendor Management: Expertise in coordinating with external vendors and OEMs for service contracts, maintenance, calibration, and addressing equipment failures or breakdowns. Project Coordination: Ability to manage and execute facility modification projects, ensuring timely delivery and alignment with operational needs. Safety & Compliance: Sound knowledge of safety practices, hygiene, sustainability programs, and regulatory compliance within facility and equipment operations. Competencies: Attention to Detail: High level of attention to detail in handling documentation, operational processes, and safety practices. Problem Solving: Strong analytical skills to troubleshoot and resolve issues in equipment, systems, and processes. Interpersonal & Communication Skills: Excellent communication and interpersonal skills to effectively collaborate with internal teams, external vendors, and service providers. Project Management: Ability to manage projects efficiently, ensuring all modifications, installations, and maintenance activities are completed on time and within scope. Team Collaboration: Team-oriented mindset with a collaborative approach to work alongside internal departments and external contractors/service providers. Adaptability: Ability to adapt to changing priorities, work in dynamic environments, and manage multiple tasks simultaneously. Qualification : Diploma/BE in electrical and electronics, with QMS related certifications with 10+Years of experience.