Senior Research Scientist - Biology Job in O2h Technology Private Limited

Senior Research Scientist - Biology

Job description

• Reporting directly to the head of biology, lead a group of in vitro assay biologists, coaching group members to improve skills and productivity

• Independently design, conduct, optimize and proactively troubleshoot assays

• Develop, optimize and validate biochemical and cellular assays for the hit to lead identification, lead optimization and functional characterization of small molecules

• Work on the bench implementing state-of-the-art technologies for the different assay platforms - managing, motivating and training junior members within the group

• Ensure robust and high quality assays with efficient use of automation and instrumentation

• Data processing, interpretation and presentation to cross functional team members and stakeholders

• Proposing, planning, quoting, tracking reagent needs, usage and executing time lines for each study

• Work closely with other biology groups involved in screening, protein biology and ADME, offering integrated drug discovery support alongside chemistry for multiple client-based projects

Job requirements

• Strong expertise in basic molecular biology, cell biology and biochemistry techniques

• Expertise in site-directed mutagenesis, transcriptional studies, luciferase reporter assays and qRT-PCR

• Working knowledge of CRISPR-CAS9 knock-out and/or siRNA/shRNA knock-down studies

• Extensive cell culture experience and in handling different immortalized, primary cell lines and 3D cultures

• Ability to perform transient transfections and generate stable cell lines

• Good working knowledge of immunoprecipitation and Western blotting for protein analysis and quantification

• Experience in fluorescence microscopy and high-content imagining is an added benefit

• Experience in targeted protein degradation, target engagement assays (e.g. nanoBRET, CETSA) is an added benefit

• Managerial experience of junior scientists

• Excellent data analysis and interpretation skills

• Ability to participate in project team meetings and contribute in the project(s) intellectually

• An ability to overcome technical challenges and exercise sound judgment under pressure

• High self-motivation to initiate projects and work independently under aggressive deadlines

• A strong technical knowledge with exceptional attention to detail

• An excellent personal rapport and an ability to engender trust and respect

• An ability to work well as part of a small focussed team and build relationships

• An exceptional communication skills and an ease in interaction with all stakeholders

• An infectious enthusiasm for life, work and making a difference to the world in which we live

• A bright, friendly, flexible personality with agility to switch between different skill sets

• An exceptional organisational skills that thrives working in a fast-paced and vibrant team environment

• Positivity, focus and a winning mentality allied with kindness

• Curiosity, energy, creativity, and bravery with a strong desire to help to build the o2h culture