Research Associate-oligonucleotide R&d Job in Syngene International Limited

Designation: Research Associate-Oligonucleotide R&D

Job Location: Bangalore

Department: Pharmaceutical Development

About Syngene

Incorporated in 1993, Syngene International Ltd. is an innovation-focused global discovery, development and manufacturing organization providing integrated scientific services to the pharmaceutical, biotechnology, nutrition, animal health, consumer goods and specialty chemical industries around the world. Syngene s clientele includes world leaders such as Bristol-Myers Squibb, Baxter, Amgen, GSK, Merck KGaA and Herbalife. Its innovative culture is driven by the passion of its 4240- strong team of scientists who work with clients from around the world to solve their scientific problems, improve R&D productivity, speed up time to market and lower the cost of innovation.

Job purpose

To support lab scale automated oligonucleotide production and purification at Syngene.

Key Responsibilities:

• The candidate is expected to help in process development in the laboratory and provide technical inputs and hands on support to ongoing projects, based on thorough literature information or evaluation of available experimental data.
• Knowledge of chemical reaction optimization and experience in anion exchange chromatography and ultrafiltration is essential. Having previous oligonucleotide/peptide synthesis experience is desirable.
• Design and execute the automated solid-phase oligonucleotide synthesis and purification at small to mid-scale.
• Method development for improved oligonucleotide synthesis and purifications, that can be translated to pilot scale production.
• Operate, maintain & troubleshoot oligonucleotide synthesis instruments, purification instruments and other scientific equipment.
• Supporting process engineers/production personal for the development of the processes feasible to execute at the manufacturing facility.
• Ability to develop a deep knowledge about oligonucleotide synthetic chemistry and probable troubleshooting. The candidate must have flexibility to learn new chemistry and techniques related to oligonucleotide synthesis.
• Transfer of chromatography and ultrafiltration processes from small scale to the large scale.
• Possess the knowledge and exposure to environment, health, and safety (EHS) practices
• Ensure environment, health, and safety (EHS) measures are always training and adhered within the team

Educational Qualification:

M.Sc in Biotechnology

Technical/functional Skills:

• Experience in working in a Biological/Peptide/Oligonucleotides upstream/downstream laboratory.
• Experience in setting up experiments and generate data suitable for technology transfer and execution at large scale.
• Good understanding of synthetic organic chemistry and solid phase synthesis.
• Experience in Unicorn software is desirable but not essential.
• Should be able to understand software interface for the various requirements in oligo synthesizer, Ultrafiltration or Chromatography.

Experience:

• 1-3 years post qualification

Behavioral Skills:

• Should have the capability to work in a team and ability to handle demonstrate a good team spirit.
• While possessing a good ability to follow instruction should also demonstrate innovative in his/her approach, good communication skills.
• Should be proactive while working on allotted responsibility.

Equal Opportunity Employer:

It is the policy of Syngene to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by applicable legislation or local law. In addition, Syngene will provide reasonable accommodations for qualified individuals with disabilities.