Research Investigator-drug Transporter Research Job in Syngene International

JOB DESCRIPTION

Designation: Research Investigator/ Principal Investigator

Job Location: Bangalore

Department: Discovery Biology

About Syngene

Incorporated in 1993, Syngene International Ltd. is an innovation-focused global discovery, development and manufacturing organization providing integrated scientific services to the pharmaceutical, biotechnology, nutrition, animal health, consumer goods and specialty chemical industries around the world. Syngene s clientele includes world leaders such as Bristol-Myers Squibb, Baxter, Amgen, GSK, Merck KGaA and Herbalife. Its innovative culture is driven by the passion of its 4240- strong team of scientists who work with clients from around the world to solve their scientific problems, improve R&D productivity, speed up time to market and lower the cost of innovation.

Job Purpose

• Scientific leadership role to establish Drug Transporter Protein Sciences Research Group
• Interact with cross functional scientific teams and external collaborators and remain as a subject matter expert in the field of transporter protein sciences
• Identification of likely transporter interactions of lead compounds and provide mitigation strategy
• Build capability to understand physchem properties that are related to the transporter protein liabilities in drug discovery programs
• Preparation of IND packages to support investigative studies that are part of regulatory submissions

Key Responsibilities:

• Develop tools and reagents to investigate role of drug transporters in the disposition of small molecules
• Integration of study results obtained from suspension and plateable hepatocytes to assess the contribution of uptake clearance mechanism in the overall disposition
• Seamless coordination with in vivo DMPK group to design in vivo studies for integration of in vitro findings
• Design and execute In vitro uptake assays in suspension, plateable hepatocytes and in the transporter transfected cell lines
• Integration of mechanistic ADME study results with transporter protein functionally and provide directions for the progression of molecules
• Preparation of SOPs and EOPs
• Reporting of the executed studies with high level of data integrity
• Reporting of study results clearly in the cross functional scientific meetings
• Follow environment, health, and safety (EHS) requirements at all times in the workplace ensuring individual and lab/plant safety
• Ensure environment, health, and safety (EHS) measures are imparted via training and adhered within the team

Educational Qualification:

Technical/functional Skills:

• Comprehensive understanding of in vitro ADME assays and technical expertise in trouble shooting the assays
• Several years of experience in conducting In vitro cell based assays using suspension and plateable hepatocytes and transporter (OATPs, OAT, OCT and MATES) transfected cell lines
• In depth understanding of biochemical and aspects of enzyme kinetics is highly desirable related to the transporter proteins
• Reasonable understanding of PBPK aspects and DDI risk assessment related to transporter proteins are essential
• Demonstrated cross functional leadership capabilities
• Experience with automation is desirable

Experience:

• A Ph.D. in pharmaceutical sciences or biological science. Five or more years of Post-doctoral and/or Industrial experience in transporter protein sciences research.

Behavioral Skills:

• Demonstrate ability to be a team player.
• Commitment to deliver the study reports within the agreed timelines
• Adaptability to changes in the dynamic lab environment
• Communicate confidently with colleagues and collaborators in the meetings and presentation of study reports and evidence of publications in the PEER reviewed Journals

Equal Opportunity Employer:

It is the policy of Syngene to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by applicable legislation or local law. In addition, Syngene will provide reasonable accommodations for qualified individuals with disabilities.